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NCT01137643Recruiting

Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer

UNC Lineberger Comprehensive Cancer Center

Start Date

7/1/2009

Completion Date

7/1/2040

Summary

RATIONALE: Collecting and storing samples of tissue, blood, and body fluid from patients with cancer to study in the laboratory may help the study of cancer in the future. PURPOSE: This research study is collecting and storing blood and tissue samples from patients being evaluated for hematologic cancer.

Detailed Description

OBJECTIVES: * Provide source of patient tissue, blood, and body fluid samples for ongoing diagnostic, prognostic, or immune-monitoring studies. * Support and enhance translational, clinical and basic research for Lineberger Comprehensive Cancer Center (LCCC) members (and non-members who have an LCCC member as sponsor and collaborator) with IRB-approved studies. * Maintain responsible and appropriate policies and procedures that ensure good patient care and responsible conduct of research. * Address medical and legal issues, and protect participant and patient privacy and confidentiality. * Provide a responsible and uniform mechanism for the integrated coordination of the hemato-pathologist and surgeon or hematology/oncology staff, researcher, and protocol office to obtain appropriate specimens for researchers. * Support young investigators to obtain pilot data for grant funding. OUTLINE: Patients undergo tissue, blood, and body fluid collection during diagnostic or routine procedures for future correlative studies. Tissue samples may include, but are not limited to, lymph node or non-nodal biopsies, bone marrow biopsy and/or aspirate, blood and serum, and buccal swabs for germline DNA analysis.

Eligibility Criteria

Age Range: 18 years to 120 years

DISEASE CHARACTERISTICS: * Diagnosis of abnormal hematopoietic/lymphoid cancer, including any of the following: * Acute myeloid leukemia * Acute lymphoblastic leukemia * Chronic myelogenous leukemia * Chronic lymphoid leukemia * Non-Hodgkin lymphoma * Hodgkin lymphoma * Myelodysplastic syndromes * Myeloproliferative disorders * Multiple myeloma * Waldenstrom macroglobulinemia * Aplastic anemia * Any other diseases that generate abnormalities in either number, function, or both of any cell type of hematolymphoid lineage * Patients who are being evaluated at the hematology/oncology clinics of the University of North Carolina Hospitals, at the stem cell transplant clinic, or in the hospital PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Interventions

OTHER

biologic sample preservation procedure

OTHER

cytology specimen collection procedure

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Conditions

Chronic Myeloproliferative DisordersLeukemiaLymphomaLymphoproliferative DisorderMultiple Myeloma and Plasma Cell NeoplasmMyelodysplastic SyndromesMyelodysplastic/Myeloproliferative NeoplasmsNonmalignant Neoplasm

Locations

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

Chapel Hill, North Carolina 27599-7295

United States