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NCT02357654PHASE4Recruiting

GnRH for Luteal Support in IVF/ICSI/FET Cycles

University Reproductive Associates

Start Date

11/1/2015

Completion Date

7/1/2026

Summary

During IVF cycles an embryo is generally placed into the uterine cavity between 3 and 5 days after fertilization. For a successful pregnancy to take place, that embryo must then implant in the properly primed and staged endometrium, which subsequently must continue to develop to accommodate the growing and maturing embryo and then fetus. This process is normally regulated by hormonal interactions between the fetal, endometrial and luteal tissue. It has been found that after IVF additional support for the endometrium with progesterone improves implantation and subsequent live birth rates in IVF cycle . Recent data has shown that additional supplementation with a single administration of a GnRH agonist around the time the time of embryo transfer may further enhance these rates .

Detailed Description

see above

Eligibility Criteria

Age Range: 18 years to 40 years

Inclusion Criteria: * women undergoing IVF/ICSI or frozen embryo transfers (FET) that less than 40 years old. Exclusion Criteria: * day 3 transfers

Interventions

DRUG

GnRH

DRUG

placebo

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Conditions

Infertility

Locations

University Reproductive Associates

Hasbrouck Heights, New Jersey 07604

United States