Third Party Viral Specific T-cells (VSTs)
Start Date
9/2/2015
Completion Date
12/1/2027
Summary
The purpose of this study is to demonstrate that viral specific T-cells (a type of white blood cell) can be generated from an unrelated donor and given safely to patients with viral infections.
Detailed Description
Viral reactivation and infection is a major cause of morbidity in immunocompromised patients (including HSCT recipients). In this study we will draw blood from unrelated (third party) donors and use the blood to generate viral specific T-cells (VSTs) with specificity for Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus (ADV), BK virus (BKV), and JC Virus. The VSTs will be infused into immunocompromised children with specific viral infections (EBV, CMV, ADV, BKV , or JC virus). Cells will be selected for infusion based on the recipient's HLA type and the viral specificity of the cells.
Eligibility Criteria
Age Range: No minimum to No maximum
Interventions
Viral Specific VST Infusion
Conditions
Locations
Akron Children's Hospital
Akron, Ohio 44308
United States
University of Cincinnati Medical Center
Cincinnati, Ohio 45219
United States
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio 45229
United States
The Ohio State University Wexner Medical Center - James Cancer Hospital
Columbus, Ohio 43210
United States