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NCT02967068Recruiting

VCRC Tissue Repository

University of Pennsylvania

Start Date

11/1/2016

Completion Date

12/1/2028

Summary

The purpose of this study is to collect existing tissue specimens from subjects enrolled in Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens and linked clinical data collected through VCRC studies may lead to the identification and development of a series of translational research projects. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

Detailed Description

Biopsy specimens collected as standard of care for these diseases will be retrieved and used in research. The most common biopsies performed are kidney, lung, skin, nerves, and vessels; however, other tissue is also of interest for the study. Biopsies are not performed as part of this protocol, rather we will request consent to collect biopsy specimens already collected under routine care.

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria: * A participant will be deemed eligible for this study if the participant is/was enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503, 5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522, 5523, 5526, 5527, or 5562). Exclusion Criteria: * Inability to give informed consent (or their guardians in the case of children) and to sign the consent form. * Unwilling to allow the use of their tissue for research.

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Conditions

AortitisCutaneous VasculitisEosinophilic Granulomatosis With PolyangiitisGiant Cell ArteritisGranulomatosis With Polyangiitis (Wegener's)Henoch-Schonlein PurpuraIgA VasculitisMicroscopic PolyangiitisPolyarteritis NodosaTakayasu ArteritisChurg-Strauss Syndrome

Locations

Brigham and Women's Hospital

Boston, Massachusetts 02115

United States

Boston University School of Medicine

Boston, Massachusetts 02118

United States

Cleveland Clinic

Cleveland, Ohio 44195

United States

University of Pennsylvania

Philadelphia, Pennsylvania 19104

United States

University of Pittsburgh

Pittsburgh, Pennsylvania 15261

United States

University of Utah

Salt Lake City, Utah 84132

United States

St. Joseph's Healthcare

Hamilton, Ontario L8N 3B6

Canada

University of Toronto Mount Sinai Hospital

Toronto, Ontario M5G 1X5

Canada