NCT03297775Recruiting
Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease
University of Colorado, Denver
Start Date
6/22/2017
Completion Date
6/1/2027
Summary
The overall goal of this study is to define the phenotype of Interstitial Lung Disease (ILD), and identify factors that predict radiologic progression in those with subclinical RA-ILD, in patients with rheumatoid arthritis (RA). The investigators hypothesize that there are common core elements (e.g. clinical features, genetic variants, and/or biologic markers) between other forms of ILD (e.g. idiopathic pulmonary fibrosis, IPF) and subclinical RA-ILD that places individuals at risk for the development of lung disease.
Eligibility Criteria
Age Range: 45 years to 90 years
Inclusion Criteria:
1. ≥ 45years old
2. Diagnosis of RA using the 2010 American College of Rheumatology (ACR) criteria
Exclusion Criteria:
1. Inability to give informed consent
2. Pregnant women
3. History of interstitial lung disease
4. Evidence of other causes of diffuse parenchymal lung disease such as infection, drug toxicity, other autoimmune processes, etc.
5. Subjects over the age of 90 years old or less than 45 years old
Conditions
Rheumatoid ArthritisInterstitial Lung Disease
Locations
University of Colorado - Anschutz Medical Campus
Aurora, Colorado 80045
United States