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NCT03364803Recruiting

Collecting Information About Treatment Results for Patients With Cushing's Syndrome

Memorial Sloan Kettering Cancer Center

Start Date

11/28/2017

Completion Date

11/28/2026

Summary

The purpose of this study is to follow participants with Cushing's syndrome during the course of their routine care and to form a data registry to study long term participant outcomes.

Eligibility Criteria

Age Range: 14 years to No maximum

Inclusion Criteria: * Age 14 or older * Active or treated overt Cushing's (due to pituitary, ectopic, or adrenal tumor), mild adrenal Cushing's syndrome (MACS), or a silent corticotroph tumor * The diagnosis of CS or MACS will be made by the PI, based on the below Endocrine Society guidelines, the patient's clinical presentation, and the PI's judgment. * Diagnostic criteria for ACTH-dependent Cushing's are according to the Endocrine Society and European Society of Endocrinology guidelines and include: Elevated 24-hour urinary free cortisol (UFC), normal or elevated plasma ACTH, elevated midnight salivary cortisol levels, or classic dexamethasone suppression testing for CD (morning cortisol \> 5 ug/dL after 1 mg overnight of classic 2-day low dose test) and a pituitary lesion on MRI (in the case of pituitary Cushing's). If patient does not have any of these results, pathology of ACTH tumor may confirm presence of disease. * Diagnostic criterion for MACS is according to the European Society of Endocrinology guidelines: Classic dexamethasone suppression testing for CS (morning cortisol \>1.8 µg/dL after 1 mg overnight) and the presence of an adrenal adenoma. * Silent corticotroph tumors will be defined by surgical pathology demonstrating positivity for ACTH, in the absence of clinical and biochemical features of Cushing's syndrome. * In lieu of MRI, surgical, or laboratory reports, physician's assessment note including mention of results will also be used as source for eligibility purposes. Exclusion Criteria: * Patients with a diagnosis of iatrogenic Cushing's.

Interventions

OTHER

Cushing's QoL (Quality of Life Questionnaire)

OTHER

Nottingham Health Profile (NHP)

OTHER

Hospital Anxiety and Depression Scale (HADS)

OTHER

Perceived Stress Scale (PSS)

OTHER

Barratt's Impulsivity Scale (BIS)

OTHER

Beck Depression Inventory (BDI)

OTHER

State-Trait Anxiety Inventory (STAI)

OTHER

State Food Craving Questionnaire-State (FCQ-S)

OTHER

Trait Food Craving Questionnaire-Trait (FCQ-T)

OTHER

Visual Analogue Scale (VAS)

OTHER

Sensitivity to Reinforcement of Addictive and other Primary Rewards (STRAP-R) food variant

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Conditions

Cushing's DiseaseCushing SyndromeCushing Disease

Locations

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey 07920

United States

Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

Middletown, New Jersey 07748

United States

Memorial Sloan Kettering Bergen (Limited Protocol Activities)

Montvale, New Jersey 07645

United States

Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activity)

Commack, New York 11725

United States

Memorial Sloan Kettering Westchester (Limited Protocol Activities)

Harrison, New York 10604

United States

Memorial Sloan Kettering Cancer Center

New York, New York 10065

United States

Memorial Sloan Kettering Nassau (Limited Protocol Activities)

Uniondale, New York 11553

United States