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NCT03546387Recruiting

Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients

Memorial Sloan Kettering Cancer Center

Start Date

5/7/2018

Completion Date

5/7/2027

Summary

The purpose of this study is to see if there is a difference between the development of the brain (neurodevelopment) in children who have been treated for retinoblastoma with multiple anesthetic exposures, compared with brain development in children who have never had anesthesia.

Eligibility Criteria

Age Range: 6 years to 17 years

Inclusion Criteria: * Age ≥ 6 and \< 17 years old Exclusion Criteria: * Diagnosis of any secondary disease associated with developmental delay * History of second cancer diagnosis * Legal Blindness * Past surgery of any type, with the exception of enucleation for retinoblastoma * Past exposure to anesthesia for surgical intervention * More than one anesthesia encounter for surgical intervention before diagnosis at MSK * Past External Beam Radiation for treatment of retinoblastoma * Past systemic chemotherapy * Non-native speaker of English; however, children whose parents speak only Spanish will be included, because the tests for parents are available in Spanish

Interventions

OTHER

Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V)

OTHER

California Verbal Learning Test, Children's Version

OTHER

Beery Developmental Test of Visual Motor Integration, 6th edition

OTHER

Grooved Pegboard Test

OTHER

Behavior Assessment System for Children/Parent Report

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Conditions

Pediatric RetinoblastomaRetinoblastoma

Locations

Memorial Sloan Kettering Cancer Center

New York, New York 10065

United States