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Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia

Yale University

Start Date

11/15/2017

Completion Date

1/1/2027

Summary

To monitor the changes in central and peripheral monitors/waveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers.

Detailed Description

The primary aim of this research is to identify the most robust site for monitoring hypovolemia as well as assess changes in peripheral waveforms monitored by the pulse oximeter collected from different sites (finger, ear, forehead, and nose), blood pressure, cerebral oximetry and peripheral venous pressure during gradual hypovolemia induced by lower body negative pressure (LBNP) in healthy volunteers.

Eligibility Criteria

Age Range: 20 years to 45 years

Inclusion Criteria: \* Healthy volunteers aged 20-45 with Exclusion Criteria: * Pregnant women * Under 20 years of age * Subjects with coronary artery disease, diabetes, epilepsy and hypertension

Interventions

DIAGNOSTIC_TEST

Lower body negative pressure

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Conditions

HypovolemiaHemodynamic Instability

Locations

John B. Pierce Laboratory

New Haven, Connecticut 06520

United States