NCT03593408Recruiting

Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support

Boston Children's Hospital

Start Date

2/8/2019

Completion Date

12/1/2026

Summary

This study will measure plasma concentrations of dexmedetomidine, fentanyl, morphine and midazolam in pediatric patients supported with extracorporeal membrane oxygenation (ECMO) aiming to understand the pharmacokinetics of these drugs in this setting.

Eligibility Criteria

Age Range: No minimum to 17 years

Inclusion Criteria: * supported on ECMO * receiving one or a combination of the following drugs dexmedetomidine, fentanyl, midazolam or morphine as part of sedation management Exclusion Criteria: -none

Interventions

DRUG

Dexmedetomidine

DRUG

Fentanyl

DRUG

Midazolam

DRUG

Morphine

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Conditions

Drug Effect

Locations

Boston Children's Hospital

Boston, Massachusetts 02115

United States

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