NCT03826693PHASE2Recruiting

Efficacy of Nitrous Oxide in OCD: Pilot Study

Stanford University

Start Date

4/17/2021

Completion Date

10/1/2027

Summary

This study investigates whether the commonly used and well-tolerated inhaled anesthetic nitrous oxide can rapidly improve symptoms of OCD.

Detailed Description

Obsessive-compulsive disorder (OCD) is a chronic and disabling disorder characterized by recurrent intrusive thoughts and associated compulsive behaviors that is estimated to affect more than 3 million individuals in the US each year. This study seeks to explore whether a single inhalation of nitrous oxide gas may bring about rapid symptom relief in OCD.

Eligibility Criteria

Age Range: 18 years to 65 years

Inclusion Criteria: * Age 18-65 * Primary diagnosis of OCD * Sufficient severity of OCD symptoms * Ability to tolerate a treatment-free period * Capacity to provide informed consent Exclusion Criteria: * Psychiatric or medical conditions that make participation unsafe * Pregnant or nursing females * Concurrent use of any medications that might increase the risk of participation (e.g. drug interactions)

Interventions

DRUG

Nitrous Oxide

DRUG

Nitrogen

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Conditions

Obsessive-Compulsive Disorder

Locations

Stanford University

Stanford, California 94304

United States