NCT03855800NARecruiting

Molecular Detection of Advanced Neoplasia in Pancreatic Cysts

Mayo Clinic

Start Date

5/11/2018

Completion Date

12/30/2030

Summary

Researchers are trying to find out whether new tests ("biomarkers") of blood, stool, pancreas cyst fluid, or pancreas juice can be used to diagnose malignant or pre-malignant changes in pancreas cysts.

Detailed Description

Subjects with Fukuoka Worrisome (FW) or Fukuoka High Risk (FHR) pancreatic cysts will be enrolled and assigned to Immediate Surgery or Clinical Follow-up groups based on clinical management as determined by the treating physicians. Blood, stool, pancreas cyst fluid, and pancreas juice specimens will be collected from participants.

Eligibility Criteria

Age Range: 18 years to 120 years

Inclusion Criteria: * Patients with pancreatic cystic lesions meeting Fukuoka worrisome or Fukuoka high-risk criteris * Patients with suspected cystic neoplasm of the pancreas * Able to provide written informed consent Exclusion Criteria: * Pregnant and/or nursing * Incarceration * Imaging showing possible pancreatic cancer * Prior history of pancreatic cancer or pancreatic surgery * History of receiving systemic chemotherapy or abdominal radiation within the last 5 years * Previous therapy for a pancreatic cystic lesion * History of pancreatic necrosis * Diagnosis of cancer (other than non-melanoma skin cancer) within the last 5 years

Interventions

DIAGNOSTIC_TEST

Blood, stool, pancreatic juice and cyst fluid collection

PROCEDURE

Pancreatic Surgery

PROCEDURE

Endoscopy Exam

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Conditions

Pancreas Cyst

Locations

Mayo Clinic

Rochester, Minnesota 55905

United States