Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy
Start Date
9/16/2019
Completion Date
10/30/2026
Summary
Readmission rates for patients with hepatic encephalopathy due to end stage liver disease are high. Hyperammonemia contributes significantly to encephalopathy and occurs because of impaired hepatic ureagenesis and increased skeletal muscle proteolysis. We propose a randomized, 6-month nutritional intervention in cirrhotic patients who have had at least 1 admission for hepatic encephalopathy within the last 6 months. We hypothesize that a combination of late evening and early morning protein supplement (Ensure Enlive) will decrease recurrent hepatic encephalopathy and consequent readmission rates by lowering skeletal muscle proteolysis and improved lean body mass.
Eligibility Criteria
Age Range: 18 years to 75 years
Interventions
Ensure Enlive
Standard Of Care
Conditions
Locations
Cleveland Clinic Foundation
Cleveland, Ohio 44195
United States