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NCT04102566PHASE4RecruitingAccepts Healthy Volunteers

Optimizing Pain Control in Transurethral Resection of the Prostate

Benaroya Research Institute

Start Date

12/8/2017

Completion Date

12/1/2019

Summary

The purpose of this study is to develop a multi-modal protocol for pain management after TURP that minimizes opioid use. The investigators hypothesize this approach will provide non-inferior pain control to the current standard of care which includes opioids as the primary agent. The investigators believe this is an important step in reducing the opioid epidemic in surgical patients.

Detailed Description

In our study, the investigators will randomize TURP patients to standard of care versus a multi-modal protocol. Multi-modal pain control is defined as: "analgesia that combines 2 or more agents that act by different mechanisms to provide analgesia with better pain relief and less opioids". In addition, patients in the intervention arm will receive education regarding pain control and opioid use. The investigators aim to demonstrate non-inferior pain control with this approach. The investigators hope this will inform new guidelines for pain control after TURP, minimize opioid use in this patient population, and educate physicians and patients on providing excellent pain control while minimizing the risks of opioid use. The investigators believe this could ultimately serve as a model for other endoscopic urologic procedures as well.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Are identified as candidates for TURP * Are 18 years of age or greater * Are proficient in English Exclusion Criteria: * Have filled an opioid prescription in the last 2 months * Have an allergy to a medication included in the protocol * Have a history of pelvic radiation * Have renal failure (Serum Cr \> 2.0 mg/dl), peptic ulcer disease, history of gastric bypass, cirrhosis, or other contraindication precluding use of NSAID's * Have liver failure, hepatitis, or alcohol abuse which precludes use of acetaminophen

Interventions

DRUG

Ibuprofen 600 mg

BEHAVIORAL

Education

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Conditions

PainBPH With Urinary ObstructionBPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms

Locations

Virginia Mason Medical Center

Seattle, Washington 98101

United States