NCT04142047RecruitingAccepts Healthy Volunteers

Skeletal Muscle Energetics and Fatiguability in Older Individuals

Johns Hopkins University

Start Date

9/5/2019

Completion Date

7/1/2027

Summary

The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

Detailed Description

This research is being done to better understand why some older people living with HIV experience more fatigue and difficulty exercising than older people without HIV. This is important because fatigue and problems exercising are predictors of disability and hospitalization in older individuals. We will use non-invasive magnetic resonance imaging (MRI) and spectroscopy (MRS) of the leg muscle to measure muscle metabolites and fat content, as well as blood samples measures levels of inflammation.

Eligibility Criteria

Age Range: 60 years to 90 years

Inclusion Criteria: * Participants who are \>= 60 years of age * HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (\<100 copies). * HIV serostatus negative participants Exclusion Criteria: * Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent * Contraindications to MRI * Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity * Significant lower extremity peripheral vascular disease. * Weight greater than 350 lbs * Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.

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Conditions

HIVHIV Infections

Locations

Johns Hopkins Hospital

Baltimore, Maryland 21287

United States