NCT04232566RecruitingAccepts Healthy Volunteers

Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity

Mayo Clinic

Start Date

2/20/2022

Completion Date

12/30/2027

Summary

This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.

Eligibility Criteria

Age Range: 30 years to 70 years

Inclusion Criteria: * Undergoing gastric bypass surgery * Confirmed AUROC F=0 or F\>2 liver fibrosis * Age 30-70 years * BMI greater than 40 kg/m2 * Negative pregnancy test (female only) * Lab Values: Normal TSH Exclusion Criteria: * Autoimmune diseases * Hepatitis B or C positive * Heavy alcohol use * Active smoking history * Active cancer history * History of asthma * History of COPD * Taking Plavix or Coumadin * Blood donation within past 2 months * Glucocorticoid Therapy * Taking antihistamine on regular basis

Interventions

PROCEDURE

Bariatric surgery

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Obesity, MorbidNASH - Nonalcoholic SteatohepatitisChronic Inflammation

Locations

Mayo Clinic in Arizona

Scottsdale, Arizona 85259

United States