NCT04295486PHASE2Recruiting
Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For VTE Following Total Joint Arthroplasty
University of Miami
Start Date
3/1/2021
Completion Date
3/1/2027
Summary
This research study is attempting to answer the question of whether 81 mg aspirin once daily is as effective as 81 mg aspirin twice daily in preventing blood clots after total joint replacement surgery.
Eligibility Criteria
Age Range: 19 years to No maximum
Inclusion criteria:
* \> 18 years of age
* Planning to undergo a primary total hip or knee arthroplasty
Exclusion Criteria:
* High risk patients for VTE as defined by:
* History of venous thromboembolism
* Active malignancy
* Known pro thrombotic condition
* BMI \> 40
* Patients requiring anticoagulation for pre-existing conditions
* Patients with the contraindication for use of aspirin or nonsteroidal antiinflammatory drugs for reasons such as peptic ulcer disease, intolerance, others.
* Patients not fluent in the language of the informed consent form
* Prisoners
* Pregnancy
* Reported to have mental illness or belonging to a vulnerable population
Interventions
DRUG
Aspirin
Conditions
Venous Thromboembolism
Locations
University of Miami Hospital
Miami, Florida 33136
United States