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NCT04383808NARecruitingAccepts Healthy Volunteers

Clinical Translation of a Novel Brain PET Insert for Simultaneous PET/MR

Stanford University

Start Date

4/1/2025

Completion Date

3/31/2028

Summary

The primary goal of this project is to study the feasibility of a brain-dedicated PET insert for an MR scanner for simultaneous acquisition of PET/MR images of human brains. The study will also allow us to compare the imaging performance of the investigator's brain-dedicated PET insert against a commercial whole-body permanently integrated PET/MRI system using a common radiopharmaceutical.

Detailed Description

This study will enroll up to 40 participants. 1. 20 participants at Stanford injected with an FDA-approved PET tracer (e.g. amyloid, FDG, etc.), and 2. 20 participants from Stanford who have been pre-injected with a radiopharmaceutical for a study on another PET imaging system

Eligibility Criteria

Age Range: 21 years to No maximum

Inclusion Criteria: 1. Whole body radiation dose within the last year of less than 5000 mrem 2. Subjects intended for injected tracer studies (not associated with another study) must be willing/able to undergo injection of 6-12 mCi of either FDG or Neuraceq radiotracer. Both tracers are FDA approved 3. Subjects will be at least 21 years of age 4. Subject provides written informed consent 5. Subject is deemed healthy by the PI by via self-reported questionnaire Exclusion Criteria: 1. For patients who will be receiving a tracer injection, no known allergy to the imaging agents 2. Participant has a history of or current diagnosis of cancer 3. Participant is pregnant or nursing 4. Metallic implants (contraindicated for MRI)

Interventions

DIAGNOSTIC_TEST

Injected radiotracer with PET Insert

DIAGNOSTIC_TEST

Pre-injected group with PET insert

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Conditions

Brain Disease

Locations

Stanford University

Palo Alto, California 94305

United States