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NCT04469439Recruiting

Impact of Sinus Surgery on Individuals With Cystic Fibrosis

University of California, Los Angeles

Start Date

7/1/2020

Completion Date

1/31/2027

Summary

This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analyzed will include pulmonary, quality of life, and others.

Eligibility Criteria

Age Range: 18 years to 99 years

Inclusion Criteria: 1. Subjects between the ages of 18 years old (inclusive) and 99 years old (inclusive, subjects over the age of 89 will be recorded to be 89 years old). 2. Diagnosed with cystic fibrosis as established by genetic testing combined with clinical assessment and/or sweat chloride 3. Diagnosed with chronic rhinosinusitis by multidisciplinary sinusitis guidelines 4. chronic rhinosinusitis symptoms persisting beyond initial medical treatment 5. Counseled for endoscopic sinus surgery and ongoing medical therapy with each patient electing their preferred treatment Exclusion Criteria: 1. Underwent endoscopic sinus surgery in past 12 months 2. Will obtain follow up care at non-participating institutions 3. Unable to complete follow-up surveys

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Conditions

Chronic Rhinosinusitis (Diagnosis)Cystic Fibrosis

Locations

University of California, Los Angeles

Los Angeles, California 90095

United States

Stanford University

Stanford, California 94305

United States

University of Colorado

Aurora, Colorado 80045

United States

National Jewish Health

Denver, Colorado 80206

United States

University of North Carolina

Chapel Hill, North Carolina 27514

United States

Oregon Health Science University

Portland, Oregon 97239

United States

Medical University of South Carolina

Charleston, South Carolina 29425

United States

Vanderbilt University Medical Center

Nashville, Tennessee 37232

United States

University of Utah

Salt Lake City, Utah 84132

United States