Effect of Thickened Feeds on Clinical Outcomes in Children With Brief Resolved Unexplained Event
Start Date
4/1/2021
Completion Date
8/31/2026
Summary
This observational study will examine the effects of thickened feeds on clinical outcomes and healthcare utilization in infants with brief resolved unexplained event (BRUE).
Detailed Description
Brief resolved unexplained events (BRUE) are frightening episodes characterized by the appearance of life-threatening choking, pallor, cyanosis, and limpness in infants. These common events are resource-intensive and current management approaches inadequately address persistent symptoms. Infants with BRUE commonly have oropharyngeal dysphagia with aspiration, which is a modifiable risk factor for persistent symptoms, but there are no studies determining the mechanism behind this swallowing dysfunction and if swallowing interventions reduce morbidity. This is a prospective, longitudinal cohort study of infants who experienced brief resolved unexplained event receiving thickened feedings compared to those not receiving thickened feedings over 1 year.
Eligibility Criteria
Age Range: No minimum to No maximum
Interventions
Thickened feeds
Non-thickened feeds
Conditions
Locations
Boston Children's Hospital
Boston, Massachusetts 02115
United States