NCT04582279NARecruitingAccepts Healthy Volunteers

Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Lung Transplant Recipients

Mayo Clinic

Start Date

10/28/2020

Completion Date

12/30/2026

Summary

This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.

Detailed Description

Lung transplant recipients are at high risk for lung rejection and lung infection after transplant. This is diagnosed by performing lung bronchoscopies and lung biopsies. These procedures carry an increased risk for complications and are costly. This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Adult patients (\> 18 yrs) who had undergone single/double/heart-lung transplant * Asymptomatic * Normal spirometry defined as a FEV1 without significant drop from baseline (significant drop = \>10% decrease from baseline) * Clear chest radiograph over allograft Exclusion Criteria: * Patients who are unable to consent for the procedure * Patients with subcutaneous emphysema or other technical challenges that could interfere with satisfactory image acquisition- as deemed by the operator.

Interventions

DIAGNOSTIC_TEST

Lung ultrasound

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Conditions

Post-Lung Transplantation Bronchiectasis

Locations

Mayo Clinic in Florida

Jacksonville, Florida 32224

United States