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NCT04676802PHASE2Recruiting

Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone

Stanford University

Start Date

12/27/2021

Completion Date

8/1/2027

Summary

In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase. Given the highly addictive nature of prescription opioids, guidelines are being evaluated by hand surgeons to reduce opioid use while still maintaining pain control after surgery. A promising approach is to use non-narcotic medication as the first line of treatment. The purpose of this study is to demonstrate the efficacy of a combination of non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen and acetaminophen, in comparison to a morphine analogue substance (oxycodone) for pain management in the first 30 days after surgery.

Eligibility Criteria

Age Range: 45 years to No maximum

Inclusion Criteria: * Undergoing trapeziectomy for thumb osteoarthritis English proficient, Exclusion Criteria: * Pregnancy Current use of opioids Concurrent surgeries (ex. trapeziectomy combined with carpal tunnel release) Inability to complete study forms (education, cognitive ability, mental status, medical status) Allergy or intolerance to Ibuprofen, Acetaminophen and/or Oxycodone Liver or kidney dysfunction, abnormal liver enzymes restricting use of acetaminophen or ibuprofen History of chronic heart failure, upper gastrointestinal bleeding or coagulopathy History of complex regional pain syndrome

Interventions

DRUG

NSAID capsules

DRUG

Opioid capsule

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Conditions

Pain, PostoperativeOsteoarthritis Thumb

Locations

Stanford Health Care

Redwood City, California 94063

United States

University of Utah Health Care

Salt Lake City, Utah 84112-

United States