Cerebrospinal Fluid Biomarkers for Brain Tumors

Inclusion Criteria: * Any evidence of neoplasm involving the central nervous system (CNS) or its adjacent structures in contact with CSF. Such lesions may include but are not limited to intra-axial or extra-axial lesions, which could be benign, malignant or as yet undefined, involving the brain, spine, meninges, nerves, or vasculature or supporting structures * Subjects must be 18 years of age or older Exclusion Criteria: * Patients who are under 18 years of age or are a member of a vulnerable population will be excluded from this study * Pregnant women or women who may be pregnant are specifically excluded from study participation * Exception will be granted for patients with diminished capacity to consent if a legally authorized representative is available * Patients without clinical or radiographic evidence of a potentially neoplastic CNS lesion will be excluded * Patients with an inability or unwillingness of individual or legal guardian/representative to give written informed consent will be excluded * Any patient for whom a clinical contraindication exists to the intended route of CSF access will be excluded. For example, a patient with a large posterior fossa mass lesion at risk of herniation, or a patient with coagulopathy, or other contraindication to lumbar puncture would not be eligible to participate via use of lumbar puncture for CSF access