NCT04708613RecruitingAccepts Healthy Volunteers
University of Pittsburgh Brain Health Initiative
David Okonkwo, MD, PhD
Start Date
11/18/2019
Completion Date
12/1/2026
Summary
This project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehensive assessment of clinical, neuroimaging, and biomarker measures.
Eligibility Criteria
Age Range: 29 years to 59 years
Inclusion criteria:
Former professional football player/exposed group:
1. Professional football retiree aged 29-59
2. Played a minimum of 3 professional football seasons, with a minimum of 3 games in each season
3. Fluent in English (translations are not available/validated for most neuropsychological tests)
Control/unexposed group:
1. Age 29-59 male
2. High school education or beyond
3. Fluent in English (translations are not available/validated for most neuropsychological tests)
Exclusion criteria:
Control/unexposed group:
1. Played organized football beyond high school
2. History of severe TBI
3. Current unstable cardiovascular disorder
For both groups:
1. Prior history of psychosis (such as schizophrenia), or other major neurological disorder that would interfere with testing, in the opinion of the primary investigator.
2. Contraindication to MR imaging, such as ferrous metal, pacemakers, or concerns about claustrophobia
Interventions
DIAGNOSTIC_TEST
Cognitive/Neuropsychological Testing
DIAGNOSTIC_TEST
Vestibular/Ocular-Motor Testing
DIAGNOSTIC_TEST
Sleep Evaluation
DIAGNOSTIC_TEST
MRI, High-Resolution
DIAGNOSTIC_TEST
Health & Physical Exam
DIAGNOSTIC_TEST
Physical Function
DIAGNOSTIC_TEST
Blood Testing and Biomarker Analysis
DIAGNOSTIC_TEST
Applanation Tonometry
DIAGNOSTIC_TEST
PET brain imaging
DRUG
[C-11]6-OH-BTA-1
DRUG
[F-18]AV-1451
Conditions
Traumatic Brain Injury
Locations
University of Pittsburgh Department of Neurosurgery
Pittsburgh, Pennsylvania 15213
United States