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NCT04708613RecruitingAccepts Healthy Volunteers

University of Pittsburgh Brain Health Initiative

David Okonkwo, MD, PhD

Start Date

11/18/2019

Completion Date

12/1/2026

Summary

This project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehensive assessment of clinical, neuroimaging, and biomarker measures.

Eligibility Criteria

Age Range: 29 years to 59 years

Inclusion criteria: Former professional football player/exposed group: 1. Professional football retiree aged 29-59 2. Played a minimum of 3 professional football seasons, with a minimum of 3 games in each season 3. Fluent in English (translations are not available/validated for most neuropsychological tests) Control/unexposed group: 1. Age 29-59 male 2. High school education or beyond 3. Fluent in English (translations are not available/validated for most neuropsychological tests) Exclusion criteria: Control/unexposed group: 1. Played organized football beyond high school 2. History of severe TBI 3. Current unstable cardiovascular disorder For both groups: 1. Prior history of psychosis (such as schizophrenia), or other major neurological disorder that would interfere with testing, in the opinion of the primary investigator. 2. Contraindication to MR imaging, such as ferrous metal, pacemakers, or concerns about claustrophobia

Interventions

DIAGNOSTIC_TEST

Cognitive/Neuropsychological Testing

DIAGNOSTIC_TEST

Vestibular/Ocular-Motor Testing

DIAGNOSTIC_TEST

Sleep Evaluation

DIAGNOSTIC_TEST

MRI, High-Resolution

DIAGNOSTIC_TEST

Health & Physical Exam

DIAGNOSTIC_TEST

Physical Function

DIAGNOSTIC_TEST

Blood Testing and Biomarker Analysis

DIAGNOSTIC_TEST

Applanation Tonometry

DIAGNOSTIC_TEST

PET brain imaging

DRUG

[C-11]6-OH-BTA-1

DRUG

[F-18]AV-1451

Interested in This Trial?

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Conditions

Traumatic Brain Injury

Locations

University of Pittsburgh Department of Neurosurgery

Pittsburgh, Pennsylvania 15213

United States