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NCT04715178RecruitingAccepts Healthy Volunteers

Beat Childhood Cancer Specimen Banking and Data Registry

Giselle Sholler

Start Date

2/2/2021

Completion Date

1/1/2032

Summary

This is an observational data registry study of pediatric cancer patients at participating Beat Childhood Cancer Consortium sites involving specimen banking and data collection.

Detailed Description

This observational registry and banking study is being performed on a large cohort of subjects who have received molecular testing to better understand the relationship between genomic and molecular information and clinical outcomes, and to enable timely and informed treatment decisions by physicians for their cancers. We hypothesize that large gene panels, sequencing (DNA/RNA), and epigenetics of tumors can identify molecular aberrations that can be leveraged to offer more effective treatment. Findings may highlight additional areas of research required to better understand the molecular underpinnings of the relationship between molecular abnormalities and disease. Banked specimens and the creation of tumor cell lines and xenograft models will facilitate further advancement of this research.

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria: * No age restrictions * Subjects that fit into one of the following categories: 1. Subjects with suspected or confirmed cancers of childhood, adolescence, or young adulthood. 2. Survivors of a cancer of childhood, adolescence, or young adulthood (\> 6 months off last therapy for cancer) 3. Subjects with a disease-matched condition 4. Healthy volunteers- including any participants with medical conditions that are not disease-matched. * Written informed consent in accordance with institutional and FDA guidelines must be obtained from all subjects (or subjects' legal representative). Exclusion Criteria: * Subject or his/her legally authorized representative (where applicable) did not consent for specimen banking and data collection for this study.

Interventions

OTHER

No intervention- registry only

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Conditions

Pediatric CancerSurvivorship

Locations

Arkansas Children's Hospital

Little Rock, Arkansas 72202

United States

Rady Children's Hospital

San Diego, California 92123

United States

Connecticut Children's Hospital

Hartford, Connecticut 06106

United States

Nicklaus Children's Miami

Miami, Florida 33155

United States

Arnold Palmer Hospital for Children

Orlando, Florida 32806

United States

St. Joseph's Children's Hospital

Tampa, Florida 33614

United States

University of Iowa

Iowa City, Iowa 52242

United States

Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine

Louisville, Kentucky 40292

United States

Children's Hospital and Clinics of Minnesota

Minneapolis, Minnesota 55404

United States

Children's Mercy Hospitals and Clinics

Kansas City, Missouri 64108

United States

Cardinal Glennon Children's Hospital

St Louis, Missouri 63104

United States

Levine Children's Hospital

Charlotte, North Carolina 28204

United States

AH Wake Forest Baptist - Brenner Children's Hospital

Winston-Salem, North Carolina 27157

United States

Randall Children's Hospital

Portland, Oregon 97227

United States

Penn State Milton S. Hershey Medical Center and Children's Hospital

Hershey, Pennsylvania 17033

United States

Medical University of South Carolina

Charleston, South Carolina 29425

United States

Dell Children's Blood and Cancer Center

Austin, Texas 78723

United States

Children's Hospital of The King's Daughters

Norfolk, Virginia 23507

United States