Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD
Start Date
2/4/2021
Completion Date
1/1/2028
Summary
interventional trial for off label use of high dose atorvastatin 80 mg in intermediate AMD patients and correlate recovery response measured by dark adaptation recovery time with drusen volume reduction measured by SD-OCT
Detailed Description
Dark adaptation recovery time is a sensitive marker of AMD progression in intermediate AMD, largely owing to drusen volume providing a transport barrier that slows the transfer of nutrients between the choroid and photoreceptors2. Consequently, dark adaptation may provide an early indication of response vs. nonresponse, aiding case-by-case decisions on continuation of treatment when patients experience adverse side effects (e.g., elevated CPK or liver enzymes) or when atorvastatin provides insufficient lipid control in patients also at high-risk for cardiovascular disease (and switching to an alternative statin might be desirable).
Eligibility Criteria
Age Range: 50 years to 85 years
Interventions
Atorvastatin 80mg
Conditions
Locations
Massachusetts Eye and Ear Infirmary
Boston, Massachusetts 02114
United States