NCT04810858NARecruitingAccepts Healthy Volunteers

Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

Wake Forest University Health Sciences

Start Date

8/18/2021

Completion Date

5/31/2027

Summary

This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.

Eligibility Criteria

Age Range: 25 years to 59 years

Inclusion Criteria: * verified HIV status * Current marijuana use (MJ+ groups only) * No current marijuana use (MJ- groups only) * current engagement in HIV care (HIV+ participants only) * receipt of cART as first-line of treatment (HIV+ participants only) * stable cART regimen (HIV+ participants only) * undetectable HIV RNA viral load for \>1 year (HIV+ participants only) Exclusion Criteria: * Lifetime abuse for any illicit drug other than marijuana * \<9th grade education; illiteracy or lack of fluency in English * history of moderate or severe head trauma * unstable or serious neurological disorders * severe mental illness * systemic autoimmune diseases * immunotherapy * MRI contraindications

Interventions

OTHER

Multimodal, multi-parametric MRI

OTHER

Immune and cytokine profiling

BEHAVIORAL

Neuropsychological testing

Interested in This Trial?

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Conditions

CannabisHIVInflammationCognitionNeuroimaging

Locations

Biotech Place

Winston-Salem, North Carolina 27101

United States