Back to Trials
NCT04829071EARLY_PHASE1Recruiting

Cognition and Motor Learning Post-stroke

University of Southern California

Start Date

1/16/2023

Completion Date

12/14/2026

Summary

This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.

Eligibility Criteria

Age Range: 45 years to 85 years

Inclusion Criteria: * Unilateral stroke * Stroke occurred more than 6 months prior * Paresis confined to one side * Independently ambulatory (including the use of assistive devices) * Able to walk for 5 minutes without stopping * Answers no to all general health questions on the PAR-Q+ * Willingness to complete study procedures Exclusion Criteria: * Brainstem or cerebellar stroke * Aphasia (expressive, receptive, or global) * Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function * Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations * Uncontrolled hypertension (\>160/110mmHg) * Concurrent physical therapy * Claustrophobia * Significant cognitive deficit or dementia (\<20 on MoCA) * Inability to give informed consent

Interventions

BEHAVIORAL

Explicit motor learning

BEHAVIORAL

Implicit motor learning

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

StrokeCVA (Cerebrovascular Accident)

Locations

Center for Health Professions

Los Angeles, California 90033

United States