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NCT04857528Recruiting

Detecting HPV DNA in Anal and Cervical Cancers

University of Chicago

Start Date

10/6/2020

Completion Date

11/15/2027

Summary

This is a research study for individuals who have cancer associated with human papillomavirus (HPV) and are being treated with radiation as part of standard care for their cancer. Doctors leading this study will use blood tests to find out if they can detect the HPV virus in the blood of study participants before, during, and after radiation treatment. They will also collect blood and archival tumor tissue (from a previous biopsy) to perform other tests in the future that could provide more information about HPV-associated cancers and how they respond to treatment. Participation in this study will last approximately 2 years.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Stage I-III anal cancer or stage I-IVA cervical cancer that is p16+ based on immunohistochemistry. * Age ≥ 18 years * Planned to undergo radiation therapy as definitive treatment, with or without concurrent systemic therapy Exclusion Criteria: * Anal carcinoma not associated with HPV-16, 18, 31, 33, or 35 will be removed from the * Planned to undergo radiation therapy as an adjuvant or post-operative therapy

Interventions

RADIATION

Radiation Treatment With or Without Chemotherapy

OTHER

Blood Sample Collection

DIAGNOSTIC_TEST

HPV Genotyping (HPV DNA Test)

DIAGNOSTIC_TEST

Testing Archival Tumor Tissue

OTHER

Physical Exam

DIAGNOSTIC_TEST

Positron Emission Tomography Scan (PET Scan)/ Computed Tomography Scan (CT Scan)

Interested in This Trial?

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Conditions

Cervical CancerAnal CancerHPV-Related Anal Squamous Cell CarcinomaHPV-Related Cervical CarcinomaHPV-Related CarcinomaUterine Cervical Cancer

Locations

University of Illinois at Chicago

Chicago, Illinois 60612

United States

University of Chicago

Chicago, Illinois 60637

United States