NCT04875936NARecruitingAccepts Healthy Volunteers

Neurofeedback Intervention for Reading Deficits in Subacute Stroke

Kessler Foundation

Start Date

4/3/2023

Completion Date

6/30/2027

Summary

The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation. Using a novel brain imaging technique, called real-time functional magnetic resonance imaging (fMRI) neurofeedback combined with right hand motor imagery, this project will re-instate brain activity in the left language-dominant hemisphere. Stroke patients will practice modulating their own brain activity using fMRI neurofeedback signal and will select the most effective mental strategies that help them maintain brain activation patterns associated with better reading recovery.

Eligibility Criteria

Age Range: 18 years to 80 years

Inclusion Criteria: * First-ever left-hemisphere stroke \< 3 months prior to study recruitment or healthy volunteer * Age: 18 - 80 years old * Fluent and literate in English prior to stroke * Reading deficits, defined as \>3 errors on the Paragraphs test (subtests VIII, IX) of the Reading Comprehension Battery for Aphasia-2nd ed. (RCBA-2) in keeping with the healthy control accuracy criterion of 86-100% correct. Exclusion Criteria: * Inability to consent or complete study tasks * Inability to undergo MRI (e.g., pregnancy, non-MRI compatible implants, claustrophobia) * A history of prior neurological disease (e.g., brain tumor, Alzheimer's disease)

Interventions

BEHAVIORAL

Motor Imagery and Real-Time fMRI Neurofeedback

BEHAVIORAL

Motor Imagery and Sham fMRI Neurofeedback

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

StrokeDyslexia, Acquired

Locations

Kessler Foundation

West Orange, New Jersey 07052

United States