NCT04946721RecruitingAccepts Healthy Volunteers

2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD

University of Maryland, Baltimore

Start Date

4/27/2022

Completion Date

12/31/2027

Summary

Evaluate and study the immunologic changes to the ocular surface in cancer patients.

Detailed Description

This is a longitudinal natural history study to evaluate and study the immunologic changes to the ocular surface in cancer patients. Two groups of subjects will be recruited for the study: 1) Pre-bone marrow transplant cancer patients. They will be evaluated every 3 months for 2 years.2) Normal control patients. They will be evaluated every 6 months for the duration of the study. During each study visit, in addition to standard of care exams, certain biological specimens ( ocular surface wash, mucocellular material, corneal filaments, or impression cytology of conjunctiva, blood, or serum) will be collected.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Adult patients (≥ 18 years of age) who visit the Eye clinic either in the UMGCCC within the UMD Hospital or the UMD Faculty Physicians Ophthalmology Practice at the UMD Professional Building or satellite locations for initial visits or established visits. * The patient must be able to understand and sign and date the informed consent form approved by the IRB. Exclusion Criteria: * Vulnerable populations: neonates, children, prisoners, institutionalized individuals. * Inability or refusal to provide informed consent. * History of ocular surgery (except refractive surgery or cataract surgery)

Interventions

DIAGNOSTIC_TEST

The standard care exam and biological specimens' collection

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Conditions

Dry Eye DiseaseoGVHD

Locations

Geenebaum Cancer Center, University of Maryland Medical Center

Baltimore, Maryland 21201

United States