NCT05174351NARecruiting
Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction
UConn Health
Start Date
12/20/2021
Completion Date
11/1/2027
Summary
This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.
Detailed Description
This is a prospective pilot study to evaluate changes before and 4 weeks(+/- 1 week) after beta-blocker withdrawal in 30 HFpEF patients. The study involves 2 visits that are 4 weeks apart. The first study visit will occur at a standard of care clinic visit and the second visit will be a research visit to fill out questionnaires and perform the limited echocardiogram. No long term follow up beyond the 2nd visit.
Eligibility Criteria
Age Range: 50 years to 80 years
Inclusion Criteria:
* Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100
* N=30 (Target: 30).
* Age: 50 \~ 80 years.
* ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction.
* Chronic loop diuretic use
* Currently on beta-blocker
Exclusion Criteria:
* Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease.
* Heart rate \> 100 bpm
* Recent hospitalization due to HF within 3 months
* Non-English speaker
Interventions
OTHER
beta blocker discontinuation
Conditions
Heart Failure With Preserved Ejection Fraction
Locations
UConn Health / John Dempsey Hospital
Farmington, Connecticut 06030
United States