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NCT05273190NARecruiting

Stimulation of the Larynx to Treat Unexplained Chronic Cough

University of Minnesota

Start Date

7/13/2021

Completion Date

6/30/2027

Summary

Researchers will test the effect of non-invasive vibrotactile stimulation of the larynx on symptom severity of unexplained chronic cough.

Eligibility Criteria

Age Range: 18 years to 88 years

Inclusion Criteria: * Adults aged 18-88 * \>8 weeks of cough * Cough visual analogue scale (VAS): Rating of 30 or greater on a 0-100 cough severity scale * Ability to provide informed consent and independently complete questionnaires * Ability to read and speak English Exclusion Criteria: * Electronic implants (e.g., pacemaker) * Currently doing speech therapy for cough * Contraindications to safe or effective VTS device use * No regular access to wifi internet Neuromuscular impairment that may affect cough/laryngeal sensation and/or function (e.g., multiple system atrophy, Parkinson, CVA, vocal fold paralysis or paresis) * Untreated carotid disease * BMI \> 40 (for transmission of VTS through soft tissue) * Current or recent (quit \< 3 months ago) smoking * Known currently infectious cause for cough (e.g., TB, pertussis, COVID) * History of known or suspected aspiration pneumonia * Diagnosis or clinical suspicion of chronic obstructive pulmonary disease (COPD) * Diagnosis or clinical suspicion of interstitial lung disease (ILD) * Unmanaged reflux * Unmanaged allergies/postnasal drip

Interventions

DEVICE

Vibrotactile Stimulation

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Conditions

Cough

Locations

University of Minnesota

Minneapolis, Minnesota 55455

United States