NCT05277025RecruitingAccepts Healthy Volunteers
Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
University of Florida
Start Date
3/22/2022
Completion Date
2/28/2027
Summary
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.
Eligibility Criteria
Age Range: 18 years to 70 years
Inclusion Criteria:
* Ages 18-70
* Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
* Fulfills the 2010 ACR-EULAR classification criteria for RA
* Healthy volunteers: No significant pain/fatigue/depression/anxiety.
Exclusion Criteria:
* Diabetes
* Cancer
* Advanced liver, kidney or cardiovascular disease
* Neuropathic pain
Conditions
FibromyalgiaRheumatoid Arthritis
Locations
University of Florida
Gainesville, Florida 32610
United States