NCT05384158NARecruiting

Valuation in Depressed Mood, Anhedonia, and Anxiety

Virginia Polytechnic Institute and State University

Start Date

8/1/2021

Completion Date

7/1/2026

Summary

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

Detailed Description

This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.

Eligibility Criteria

Age Range: 25 years to 50 years

Inclusion Criteria: * mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games. Exclusion Criteria: * history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI

Interventions

BEHAVIORAL

cognitive behavioral therapy

BEHAVIORAL

valuation with instruction

BEHAVIORAL

valuation without instruction

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Conditions

Neurobehavioral Components of Reward and Loss Valuation

Locations

Fralin Biomedical Research Institute at Virginia Tech Carilion

Roanoke, Virginia 24014

United States