NCT05419076PHASE2Recruiting
A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain
Memorial Sloan Kettering Cancer Center
Start Date
6/10/2022
Completion Date
6/10/2027
Summary
The purpose of the study is to see if stereotactic radiosurgery/SRS is an effective treatment for people with a new diagnosis of brain metastases from small cell lung cancer/SCLC.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
* Histologic diagnosis of small cell lung cancer
* Radiographic diagnosis of up to 20 brain metastases on contrast-enhanced MRI
* Age 18 and above
* Performance status KPS 60-100/ECOG 0-2
* Female patients must be of non-reproductive potential or have a negative serum pregnancy test at the time of enrollment
* The patient or legally authorized representative is able to provide informed consent
Exclusion Criteria:
* Unable to undergo contrast-enhanced MRI brain
* Leptomeningeal disease confirmed on lumbar puncture, MRI brain, or MRI spine
* Pregnant or lactating women
* Prior brain-directed radiotherapy
* Uncontrolled systemic disease without reasonable systemic therapy options felt likely to result in death as observed on CT or PET/CT imaging, no more than 3 months before study enrollment
Interventions
RADIATION
Stereotactic Radiosurgery
PROCEDURE
Cerebrospinal fluid collection
Conditions
Lung CancerLung Cancer MetastaticBrain MetastasesBrain Metastases, AdultSmall-cell Lung CancerSmall Cell Lung Carcinoma
Locations
Memorial Sloan Kettering at Basking Ridge
Basking Ridge, New Jersey 07920
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey 07645
United States
Memorial Sloan Kettering Suffolk - Commack
Commack, New York 11725
United States
Memorial Sloan Kettering Westchester
Harrison, New York 10604
United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York 10065
United States
Memorial Sloan Kettering Nassau
Rockville Centre, New York 11553
United States