A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)
Start Date
2/24/2023
Completion Date
1/2/2029
Summary
This study is open to adults with different types of advanced cancer. People can take part if previous treatment was not successful, or no treatment exists. The purpose of this study is to find the highest dose of a medicine called BI 1703880 that people with advanced cancer can tolerate when taken together with ezabenlimab. BI 1703880 and ezabenlimab are medicines that may help the immune system fight cancer. In this study, BI 1703880 is given to people for the first time. Participants get BI 1703880 and ezabenlimab as infusions into a vein. During the first 6 weeks, they get BI 1703880 once a week. Later, they get BI 1703880 every 3 weeks. After the first 3 weeks, they get ezabenlimab in addition every 3 weeks. Participants can get BI 1703880 for up to 1 year and ezabenlimab for up to 2 years as long as they benefit from treatment and can tolerate it. During this time, they visit the study site regularly. At these visits, the doctors check participants' health and take note of any unwanted effects.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
BI 1703880
Ezabenlimab
Conditions
Locations
Valkyrie Clinical Trials
Los Angeles, California 90067
United States
Yale University School of Medicine
New Haven, Connecticut 06511
United States
John Theurer Cancer Center
Hackensack, New Jersey 07601
United States
National Cancer Center Hospital East
Chiba, Kashiwa, 277-8577
Japan
Saitama Medical University International Medical Center
Saitama, Hidaka, 350-1298
Japan
Japanese Foundation for Cancer Research
Tokyo, Koto-ku, 135-8550
Japan
Seoul National University Bundang Hospital
Seongnam, 13620
South Korea
Severance Hospital
Seoul, 03722
South Korea
Asan Medical Center
Seoul, 05505
South Korea
Hospital Universitari Vall d'Hebron
Barcelona, 08035
Spain
Hospital Universitario Ramon Y Cajal
Madrid, 28034
Spain
Hospital Universitario 12 de Octubre
Madrid, 28041
Spain
CIO Clara Campal
Madrid, 28050
Spain
Instituto Valenciano de Oncología
Valencia, 46009
Spain
Hospital Clinico Universitario de Valencia
Valencia, 46010
Spain
National Cheng Kung University Hospital
Tainan, 70403
Taiwan
National Taiwan University Hospital
Taipei, 10002
Taiwan
The Royal Marsden Hospital, Chelsea
London, SW3 6JJ
United Kingdom
Churchill Hospital
Oxford, OX3 7LE
United Kingdom
The Royal Marsden Hospital, Sutton
Sutton, SM2 5PT
United Kingdom