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NCT05474430Recruiting

Estimating Risk of Respiratory Infections Attributable to CFTR Heterozygosity

Philip Polgreen

Start Date

12/20/2021

Completion Date

7/1/2026

Summary

A research team member will brush the inferior surface of the subjects' middle turbinate (nasal cavity) using a cytology brush to obtain the cells needed to perform our functional respiratory assays. An individual trained in phlebotomy will draw one 3 ml lavender top tube of blood to test c-reactive protein, calprotectin, and lactoferrin. They will also draw a 5 ml gold top serum separator tube of blood to test fibroblast growth factor-19. The participant will answer questions from the baseline survey and report their current medications interview-style with the research team member.

Eligibility Criteria

Age Range: 18 years to 100 years

CF Carrier Inclusion Criteria: * Previously tested and shown to be a CF carrier * English-speaking Control Group Inclusion Criteria: * Previously tested and shown to not be a CF carrier or CF patient * English-speaking Exclusion Criteria: * Currently sick with a respiratory infection * Prisoner Status * Unable to provide own written, informed consent

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Conditions

Carrier StateRespiratory Infections

Locations

University of Iowa Hospitals and Clinics

Iowa City, Iowa 52242

United States