NCT05474430Recruiting
Estimating Risk of Respiratory Infections Attributable to CFTR Heterozygosity
Philip Polgreen
Start Date
12/20/2021
Completion Date
7/1/2026
Summary
A research team member will brush the inferior surface of the subjects' middle turbinate (nasal cavity) using a cytology brush to obtain the cells needed to perform our functional respiratory assays. An individual trained in phlebotomy will draw one 3 ml lavender top tube of blood to test c-reactive protein, calprotectin, and lactoferrin. They will also draw a 5 ml gold top serum separator tube of blood to test fibroblast growth factor-19. The participant will answer questions from the baseline survey and report their current medications interview-style with the research team member.
Eligibility Criteria
Age Range: 18 years to 100 years
CF Carrier Inclusion Criteria:
* Previously tested and shown to be a CF carrier
* English-speaking
Control Group Inclusion Criteria:
* Previously tested and shown to not be a CF carrier or CF patient
* English-speaking
Exclusion Criteria:
* Currently sick with a respiratory infection
* Prisoner Status
* Unable to provide own written, informed consent
Conditions
Carrier StateRespiratory Infections
Locations
University of Iowa Hospitals and Clinics
Iowa City, Iowa 52242
United States