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NCT05522972NARecruitingAccepts Healthy Volunteers

Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games

Nova Southeastern University

Start Date

9/13/2022

Completion Date

8/31/2029

Summary

Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia.

Detailed Description

Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. Our previous findings (see Publications) show that the adult amblyopic brain is still plastic and malleable, suggesting that active approach is potential useful in treating amblyopia.The goal of this project is to assess the limits and mechanisms of neural plasticity in both normal and amblyopic spatial vision. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia. Research participants will be asked to practice a visual discrimination task (perceptual learning) or to play video games with the amblyopic eye for a period of time. A range of visual functions will be monitored during the course of treatment.

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria: * adults and children with normal vision or amblyopia * amblyopia: interocular VA difference of 0.1 logMAR or more Exclusion Criteria: * any ocular pathological conditions, nystagmus

Interventions

BEHAVIORAL

Video Game Vision Training

BEHAVIORAL

Perceptual Learning

BEHAVIORAL

Occlusion Therapy

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Conditions

Amblyopia

Locations

Nova Southeastern University College of Optometry

Fort Lauderdale, Florida 33328

United States