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NCT05531461Recruiting

Cognition and Imaging With Tigertriever

Rapid Medical

Start Date

10/28/2024

Completion Date

11/1/2026

Summary

The objective of the COGNITIVE Study is to evaluate whether successful reperfusion with Tigertriever is associated with cognitive benefit.

Eligibility Criteria

Age Range: 18 years to 75 years

Inclusion Criteria: 1. Patients admitted with large vessel occlusion (LVO) and treated with the Tigertriever, as indicated per the approved IFU. 2. Tigertriever was used as the first line treatment in the target vessel. 3. A signed informed consent. 4. Age 18-75 years (inclusive). 5. No known significant pre-stroke disability (pre-stroke mRS 0 or 1). Exclusion Criteria: 1. Use of any other IA recanalization device prior to the Tigertriever in the target vessel, including aspiration catheter. 2. Evidence of acute brain hemorrhage on CT and/or MRI at admission. 3. Prior hemorrhage, stroke, thrombolysis, and/or endovascular therapy in the last 3 months. 4. Probable cerebral amyloid angiopathy. 5. Pre-stroke diagnosed dementia and/or prescribed cholinesterase inhibitors. 6. Pre-stroke diagnosed and/or currently treated major depression. 7. Pre-stroke learning or intellectual disability. 8. Anticipated inability to obtain 6-month follow-up assessments. \-

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Conditions

Stroke

Locations

University of California

Los Angeles, California 90095

United States

Corewell Health Research Institute

Grand Rapids, Michigan 49503

United States

Westchester Medical Center

New York, New York 10595

United States