NCT05557864NARecruiting
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
University of Minnesota
Start Date
8/25/2016
Completion Date
12/31/2026
Summary
This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practice by providing a potential strategy to these medically intractable symptoms.
Eligibility Criteria
Age Range: 21 years to 89 years
Inclusion Criteria:
* diagnosis of idiopathic PD
* have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)
* Existing 7T brain imagery
Exclusion Criteria:
* history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs
* other significant neurological disorder
* history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR)
* post-operative complications or adverse effects
Interventions
DEVICE
Deep Brain Stimulation
Conditions
Parkinson's Disease
Locations
University Of Minnesota
Minneapolis, Minnesota 55455
United States