NCT05558241NARecruiting

Micro-UltraSound In Cancer - Active Surveillance

University of Alberta

Start Date

11/30/2022

Completion Date

7/30/2033

Summary

This study will compare the two imaging modalities (MRI and micro-ultrasound) during Active Surveillance of prostate cancer (PCa). Progression to clinically significant PCa will be assessed by first taking micro-US targeted samples (while blinded to MRI results), followed by MRI targeted samples, finishing with 12 systematic biopsy cores. The primary goal is to compare microUS to MRI for the detection of ≥GG2 PCa at confirmatory biopsy. This study will also collect blood samples from participants to be used for future biomarker studies.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Adult men with Gleason Grade Group 1 prostate cancer managed by active surveillance who require a confirmatory prostate biopsy Exclusion Criteria: * Men who cannot undergo a prostate MRI * Men who cannot undergo a prostate biopsy

Interventions

DEVICE

High-resolution micro-ultrasound

Interested in This Trial?

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Conditions

Prostate Cancer

Locations

University of California Los Angeles, Department of Urology

Los Angeles, California 90095

United States

Kipnes Urology Centre - Kaye Edmonton Clinic

Edmonton, Alberta T6G1Z1

Canada

University of British Columbia

Vancouver, Alberta V6T 1Z3

Canada

CIUSSS du Nord-de-L'Ile-De-Montreal

Montreal, Quebec H3L 1K5

Canada

University Hospital Centre Zagreb

Zagreb,

Croatia

Humanitas

Milan,

Italy