NCT05559853RecruitingAccepts Healthy Volunteers
Developing a New MRI Technique to Understand Changes in Brain Tumors After Treatment
Memorial Sloan Kettering Cancer Center
Start Date
9/22/2022
Completion Date
9/22/2027
Summary
The purpose of this study is to develop and test a new magnetic resonance imaging (MRI) technique to see if it can be used to tell the difference between tumor growth from worsening of cancer and growth from the effects of treatment in participants who have brain tumors treated with radiation therapy called stereotactic radiosurgery (SRS).
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
Healthy volunteers \[for Study Aim 1 (SA1) and Study Aim 2 (SA2)\] will be entered into the study if they meet the following criteria:
* Age ≥ 18 years
* Able to understand and give informed consent
* No known cancer diagnosis
Patients \[for Study Aim 1 (SA1)\] will be entered into the study if they meet the following criteria:
* Age ≥ 18 years
* Able to understand and give informed consent
* At least one untreated brain metastasis \> 1cm (e.g., an enhancing lesion in the brain of a patient with known systemic cancer determined likely to represent metastasis by neuroradiologist)
Patients \[for Study Aim 3 (SA3)\] will be entered into the study if they meet the following criteria:
* Age ≥ 18 years
* Able to understand and give informed consent
* At least one untreated brain metastasis \> 1cm (e.g., an enhancing lesion in the brain of a patient with known systemic cancer determined likely to represent metastasis by neuroradiologist)
* Planned SRS treatment
Exclusion Criteria:
Healthy volunteers (SA1 \& SA2) and patients (SA1 \& SA3) exclusion criteria:
* Pregnant or breastfeeding women
* Pre-existing medical conditions, including the likelihood of developing seizures or claustrophobic reactions, and any greater than normal potential for cardiac arrest
* Age \< 18 years
Interventions
DIAGNOSTIC_TEST
CEST-MRF
Conditions
Brain MetastasesBrain Metastases, AdultMetastatic Brain TumorMetastatic Brain Cancer
Locations
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York 10065
United States