NCT05693220NARecruiting

Sperm Preparation Prior to Intrauterine Insemination Study

University of California, San Francisco

Start Date

2/5/2023

Completion Date

12/31/2027

Summary

This is a randomized controlled trial comparing density gradient centrifugation and microfluidic sperm sorting in patients undergoing intrauterine insemination to evaluate cumulative pregnancy outcomes.

Detailed Description

Study participants will be randomized to either standard sperm preparation (density gradient centrifugation) versus sperm preparation with the Zymot Multi sperm preparation device for their three month intrauterine insemination treatment course. Patients will follow standard treatment plans designed by their fertility physician and will be followed until referred for prenatal care at 8-10 weeks of pregnancy to determine pregnancy outcomes.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Patients undergoing intrauterine insemination * Patient assigned female at birth with age \<41 Exclusion Criteria: * Any significant disease or psychiatric disorder that would interfere with the consenting process * Prior intrauterine insemination * Use of frozen donor sperm * Non-English speaker

Interventions

DEVICE

Zymot Multi sperm separation device

OTHER

Density gradient centrifugation

Interested in This Trial?

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Conditions

InfertilityInfertility SecondaryInfertility UnexplainedAnovulationFertility DisordersReproductive Issues

Locations

UCSF Center for Reproductive Health

San Francisco, California 94158

United States