NCT05699200NARecruitingAccepts Healthy Volunteers

A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Mayo Clinic

Start Date

6/1/2023

Completion Date

8/1/2027

Summary

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography * For controls: no cardiac disease history Exclusion Criteria: * Pregnancy * Known or suspected unstable cardiac condition within 4 weeks of the study * Active treatment with anticoagulation or dual antiplatelet therapy * Prisoner

Interventions

OTHER

Arterial Tonometry

DIAGNOSTIC_TEST

Echocardiogram

DIAGNOSTIC_TEST

Carotid Ultrasounds

DIAGNOSTIC_TEST

Elastography

OTHER

Ankle-Brachial Index

OTHER

Microneurography with sympathoexcitatory maneuvers

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Conditions

Spontaneous Coronary Artery DissectionHealthy

Locations

Mayo Clinic Rochester

Rochester, Minnesota 55905

United States