NCT05721027PHASE4RecruitingAccepts Healthy Volunteers
Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.
Montefiore Medical Center
Start Date
7/5/2023
Completion Date
10/1/2027
Summary
This will be a placebo controlled, randomized, double-blind, comparative effectiveness study, in which we patients are enrolled during an emergency department (ED) visit for acute radicular low back pain (LBP) and followed by telephone two and seven days later. Patients will be randomized to receive an oral dose of dexamethasone for 2 consecutive days or placebo during an ED visit for acute radicular LBP. Every patient will receive a 7 day supply of ibuprofen and a low back pain education session.
Eligibility Criteria
Age Range: 18 years to 70 years
Inclusion Criteria:
* Present to ED primarily for management of acute radicular LBP, defined as pain or paresthesia originating from the lower back and radiating to the buttock and or leg in a radicular pattern. Some patients may not have prominent LBP but a radicular symptom--we will include these patients as well.
* Patient is to be discharged home.
* Age 18-70 Enrollment will be limited to adults \<70 years because of the increased risk of adverse medication effects in older adults.
* Pain duration \<2 week
* Prior to the acute attack of radicular LBP, back pain cannot occur more frequently than half of the days in the last 3 months. Patients with more frequent back pain/sciatica are at increased risk of poor pain and functional outcomes.10
* Non-traumatic cause of pain: no substantial and direct trauma to the back within the previous month
* Functionally impairing radicular LBP: A baseline score of \> 5 on the Roland-Morris Disability Questionnaire
Exclusion Criteria:
* Not available for follow-up
* Pregnant
* Chronic pain syndrome defined as use of any analgesic medication on a daily or near-daily basis
* Allergic to or intolerant of investigational medications
* Chronic steroid use
* Contra-indications to investigational medications: 1) known peptic ulcer disease, chronic dyspepsia, or history of gastrointestinal bleed 2) Severe heart failure (NYHA 2 or worse) 3) Chronic kidney disease (GFR \<60ml/min) 4) Current use of anti-coagulants 5) cirrhosis (Child Pugh A or worse) or hepatitis (transaminases 2x the upper limit of normal)
Interventions
DRUG
Ibuprofen 400 mg
DRUG
Dexamethasone Oral
BEHAVIORAL
Educational Intervention
Conditions
Radiculopathy, Lumbosacral RegionBack Pain With RadiationLow Back Pain
Locations
Albert Einstein College of Medicine/Montefiore Medical Center - Weiler ED
The Bronx, New York 10461
United States
Montefiore Medical Center - Moses ED
The Bronx, New York 10467
United States