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NCT05734430RecruitingAccepts Healthy Volunteers

Genetics of Appendix Cancer Study

Andreana Holowatyj, PhD, MSCI

Start Date

11/11/2022

Completion Date

11/1/2034

Summary

The GAP Study is a prospective cohort study designed to comprehensively investigate genetic variations that may contribute to cancer development among individuals diagnosed with appendix/appendiceal cancer who are ages 18+ years.

Detailed Description

The Genetics of Appendix Cancer (GAP) Study aims to analyze hereditary factors, tumor characteristics and clinical features/outcomes among adults diagnosed with appendix cancer and their biological parents. Patients are recruited at any time after a diagnosis of appendix cancer and followed for up to 6 years after study enrollment. This cohort is enriched by robust biospecimens and data collections.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: GAP Social * Known diagnosis of appendix cancer in the United States * Mentally and physically able to consent and participate in the study GAP Vanderbilt * Known diagnosis of appendix cancer * Diagnosed by and/or consulting with a physician/clinical provider participating in the GAP Study * Mentally and physically able to consent and participate in the study GAP Parent * Biological parents (mother and/or father) of individuals actively participating in the GAP Study * Residing in the United States * Mentally and physically able to consent and participate in the study Exclusion Criteria: * Women pregnant at the time of consent * Prisoners * Unable to provide informed consent * Unable to read, write, or complete questionnaires in English

Interventions

GENETIC

Genetic profiling

OTHER

Retrospective tissue procurement

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Conditions

Appendix CancerAppendiceal CancerAppendiceal NeoplasmsAppendiceal Mucinous NeoplasmAppendiceal AdenocarcinomaAppendiceal Carcinoid TumorAppendiceal Neoplasm Malignant SecondaryAppendix AdenocarcinomaAppendix Mucinous NeoplasmAppendix TumorAppendix Cancer MetastaticAppendix NETLow-Grade Appendix Mucinous NeoplasmHigh Grade Appendix Mucinous NeoplasmHigh Grade Appendix Mucinous Adenocarcinoma

Locations

Vanderbilt-Ingram Cancer Center

Nashville, Tennessee 37232

United States