NCT05734430RecruitingAccepts Healthy Volunteers
Genetics of Appendix Cancer Study
Andreana Holowatyj, PhD, MSCI
Start Date
11/11/2022
Completion Date
11/1/2034
Summary
The GAP Study is a prospective cohort study designed to comprehensively investigate genetic variations that may contribute to cancer development among individuals diagnosed with appendix/appendiceal cancer who are ages 18+ years.
Detailed Description
The Genetics of Appendix Cancer (GAP) Study aims to analyze hereditary factors, tumor characteristics and clinical features/outcomes among adults diagnosed with appendix cancer and their biological parents. Patients are recruited at any time after a diagnosis of appendix cancer and followed for up to 6 years after study enrollment. This cohort is enriched by robust biospecimens and data collections.
Eligibility Criteria
Age Range: 18 years to No maximum
Inclusion Criteria:
GAP Social
* Known diagnosis of appendix cancer in the United States
* Mentally and physically able to consent and participate in the study
GAP Vanderbilt
* Known diagnosis of appendix cancer
* Diagnosed by and/or consulting with a physician/clinical provider participating in the GAP Study
* Mentally and physically able to consent and participate in the study
GAP Parent
* Biological parents (mother and/or father) of individuals actively participating in the GAP Study
* Residing in the United States
* Mentally and physically able to consent and participate in the study
Exclusion Criteria:
* Women pregnant at the time of consent
* Prisoners
* Unable to provide informed consent
* Unable to read, write, or complete questionnaires in English
Interventions
GENETIC
Genetic profiling
OTHER
Retrospective tissue procurement
Conditions
Appendix CancerAppendiceal CancerAppendiceal NeoplasmsAppendiceal Mucinous NeoplasmAppendiceal AdenocarcinomaAppendiceal Carcinoid TumorAppendiceal Neoplasm Malignant SecondaryAppendix AdenocarcinomaAppendix Mucinous NeoplasmAppendix TumorAppendix Cancer MetastaticAppendix NETLow-Grade Appendix Mucinous NeoplasmHigh Grade Appendix Mucinous NeoplasmHigh Grade Appendix Mucinous Adenocarcinoma
Locations
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee 37232
United States