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NCT05806996PHASE2Recruiting

A Study of Magnesium and Bladder Spasms Following Ambulatory Urologic Procedures

Mayo Clinic

Start Date

7/31/2023

Completion Date

12/31/2026

Summary

This research is being done to find out whether intravenous magnesium is effective in the treatment of bladder spasms after urologic surgery.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: \- Be undergoing a bladder invasive procedure with or without planned urinary catheter on Mayo Clinic Gonda 7 Outpatient Procedure Center. Exclusion Criteria: * Are unable to grant informed consent or comply with study procedure. * Allergy or known sensitivity to magnesium or Renacidin. * Expected or high risk of bladder extravasation. * Ongoing atrial fibrillation prior to surgery. * Are undergoing emergency surgery. * Are pregnant. * Known hypermagnesemia. * Patients with neuromuscular weakness (e.g., Myasthenia gravis) due to magnesium's muscle weakening effect. * Patients with myocardial compromise or cardiac conduction defects because of magnesium's anti-inotropic effects. * Patients with renal insufficiency, glomerular filtration rate less than 30, since Magnesium is eliminated by the kidneys resulting in exaggerated rise in serum magnesium. * Patients with concomitant use of a calcium channel blocker since magnesium sulfate could act synergistically to suppress muscular contractility.

Interventions

DRUG

Magnesium

DRUG

Placebo

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Conditions

Bladder Spasms

Locations

Mayo Clinic in Minnesota

Rochester, Minnesota 55905

United States