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NCT05838508NARecruitingAccepts Healthy Volunteers

Effect of Physical Activity Pattern on Cardiometabolic Health

Brigham and Women's Hospital

Start Date

10/11/2024

Completion Date

8/30/2026

Summary

The goal of this study is to understand the interaction between the circadian system and physical activity. Participants will: * complete 2 inpatient stays * perform moderate exercise * be provided with identical meals * have frequent blood draws * provide urine and saliva samples

Detailed Description

The endogenous circadian system (i.e., an internal biological rhythm) plays an important role in regulating blood glucose, blood pressure, and energy expenditure. Physical activity improves health and reduces the risk for cardiovascular diseases and type 2 diabetes. The goal of this study is to understand the interaction between the circadian system and physical activity. We aim to test whether such relationship between the circadian system and physical activity can be used to enhance the health benefits of physical activity.

Eligibility Criteria

Age Range: 18 years to 45 years

Inclusion Criteria: * 18-45 yr old * Body mass index (BMI) 18.5 - 34.9 kg/m2 * No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.) * Willing to adhere to the protocol requirements for the duration of the study Exclusion Criteria: * Currently smoking/vaping or 5 or more years of smoking/vaping * Currently pregnant or breastfeeding * History of drug or alcohol dependency * History of psychiatric illness or disorder * Any hospitalization due to COVID-19 * Inability to exercise for any reason * Any known contraindication to exercise testing based on current ACSM guidelines

Interventions

BEHAVIORAL

Exercise intervention

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Conditions

Life Style

Locations

Brigham and Women's Hospital

Boston, Massachusetts 02115

United States