NCT05856136PHASE4Recruiting

A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

Mayo Clinic

Start Date

6/19/2023

Completion Date

1/1/2027

Summary

The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: \- Adult male and female patients undergoing lower extremity orthopedic surgery at the study institutions (St. Mary Hospital and Rochester Methodist Hospital within the Mayo Clinic Rochester hospital system). Exclusion Criteria: * Patients who refuse research participation. * Patients who are pregnant. * Patients with known pulmonary pathology (COPD, asthma requiring routine treatment).

Interventions

DRUG

Fentanyl Injection

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Conditions

Respiratory Function LossRespiratory Complication

Locations

Mayo Clinic Minnesota

Rochester, Minnesota 55905

United States