A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.
Start Date
8/2/2023
Completion Date
6/30/2028
Summary
The study is a dose-escalation and dose-expansion study to evaluate the safety, tolerability, and pharmacokinetics of ASKG915 as a single agent or in combination with standard of care (SOC) in patients with selected types of advanced solid tumors.
Detailed Description
Monotherapy: A dose-escalation (Part A) and expansion (Part B) study of ASKG915 monotherapy was initiated to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) in patients with advanced solid tumors. Combination therapy: A dose-optimization (Part C) srudy of ASKG915 in combination with standard of care (SOC) in patients was conducted to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) in patients with selected types of advanced solid tumors.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
ASKG915
Paclitaxel + Bevacizumab
Fruquintinib
Docetaxel
Conditions
Locations
Columbia University Irving Medical Center
New York, New York 10032
United States
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania 15232
United States
Peking University Cancer Hospital
Beijing, Beijing Municipality 100089
China
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality 201321
China